Haplotype analysis of the PARK 11 gene, GIGYF2, in sporadic Parkinson's disease
Identifieur interne : 000A71 ( Main/Exploration ); précédent : 000A70; suivant : 000A72Haplotype analysis of the PARK 11 gene, GIGYF2, in sporadic Parkinson's disease
Auteurs : Greg T. Sutherland [Australie] ; Gerhard A. Siebert [Australie] ; Jeremy R. B. Newman [Australie] ; Peter A. Silburn [Australie] ; Richard S. Boyle [Australie] ; John D. O'Sullivan [Australie] ; George D. Mellick [Australie]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-02-15.
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Abstract
Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence disease risk. Recently, mutations were described in the gene, GIGYF2 (TNRC15), located at the PARK11 locus (2q37.1). Here, we use a haplotype tagging approach to examine common variation in the GIGYF2 gene and PD risk. PD cases (n = 568) and age and gender‐matched control subjects (n = 568) were recruited from three specialist movement disorder clinics in Brisbane (Australia) and the Australian electoral roll. Twelve tagging SNPs were assessed in all subjects and haplotype and genotype associations were explored. Overall our findings suggest that common genetic variants of GIGYF2 do not significantly affect sporadic PD risk in Australian Caucasians. © 2008 Movement Disorder Society
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DOI: 10.1002/mds.22427
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-02-15">2009-02-15</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="448">448</biblScope><biblScope unit="page" to="452">452</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">5C520A1A32A512B867E533B866B8964343315BB3</idno><idno type="DOI">10.1002/mds.22427</idno><idno type="ArticleID">MDS22427</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>PD‐related genes</term><term>Parkinson's disease</term><term>association</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence disease risk. Recently, mutations were described in the gene, GIGYF2 (TNRC15), located at the PARK11 locus (2q37.1). Here, we use a haplotype tagging approach to examine common variation in the GIGYF2 gene and PD risk. PD cases (n = 568) and age and gender‐matched control subjects (n = 568) were recruited from three specialist movement disorder clinics in Brisbane (Australia) and the Australian electoral roll. Twelve tagging SNPs were assessed in all subjects and haplotype and genotype associations were explored. 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